A série é baseada na sequência de livros, e trata da vida social luxuosa de Serena van der Woodsen (Blake Lively) e sua conturbada amizade com Blair Waldorf (Leighton Meester). Serena volta depois de ter se ausentado por um bom tempo e sofre com as fofocas e consequências de ter transado com Nate Archibald (Chace Crawford), namorado de sua melhor amiga Blair e melhor amigo de Chuck Bass (Ed Westwick), rapaz que só sabe pensar em sexo, sexo e sexo.A bela loira encontra apoio nos braços de Dan Humpfrey (Penn Badgley), um solitário que sempre teve Serena em seus sonhos como sua paixão platônica, porém tem sua vida atormentada pela volta de sua ex-namorada Vanessa.

1º Temporada :

1×01 – Pilot
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1×02 – The wild brunch
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1×03 – Poison Ivy
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1×04 – Bad news Blair
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1×05 – Dare Devil
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1×06 – The Handmaiden’s Tale
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1×07 – Victor, Victrola
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1×08 – Seventeen Candles
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1×09 – Blair Waldorf Must Pie
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1×10 – Hi, Society
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1×11 – Roman Holiday
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1×12 – School Lies
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1×13 – A Thin Line Between Chuck and Nate
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1×14 – The Blair Bitch Project
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1×15 – Desperately Seeking Serena
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1×16 – All About My Brother
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1×17 – Woman on the Verge
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1×18 – Much ‘I Do’ About Nothing (Season Finale)
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2º Temporada :

2×01 – Summer Kind of Wonderful
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2×02 – Never Been Marcused
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2×03 – The Dark Night
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2×04 – The Ex-Files
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2×05 – The Serena Also Rises
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2×06 – New Haven Can Wait
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2×07 – Chuck in Real Life
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2×08 – Pret-a-Poor-Jenny
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2×09 – There Might be Blood
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2×10 – Bonfire of the Vanity
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2×11 – The Magnificent Archibalds
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2×12 – It’s a Wonderful Lie
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2×13 – O Brother, Where Bart Thou?
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2×14 – In the Realm of Basses
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2×15 – Gone with the Will
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2×16 – You’ve Got Yale!
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2×17 – Carnal Knowledge
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2×18 -The Age of Dissonance
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2×19 – The Grandfather
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2×20 – Remains of the J
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2×21 – Seder Anything
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2×22 – Southern Gentlemen Prefer Blondes
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2×23 – The Wrath of Con
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2×24 – Valley Girls
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2×25 – The Goodbye Gossip Girl (Season Finale)
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3º Temporada :

3×01 – Reversals of Fortune
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3×02 – The FreshMan
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3×03 – The Lost Boy
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3×04 – Dan De Fleurette
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3×05 – Rufus Getting Married
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3×06 – Enough About Eve
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3×07 – How to succeed in bassness
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3×08 – The Grandfther Part II
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3×09 They Shoot Humphrey’s, Don’t They?
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3X10 – The Last Days of Disco Stick
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3×11 – The Treasure of Serena Madre
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3×12 – The Debarted
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3×13 – The Hurt Locket
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